Research of the correlation between body mass index and uric acid levels

Objective To investigate the correlation between body mass index (BMI) and serum level of uric acid (UA) in physical examination subjects. Methods A total of 1 514 physical examination subjects older than 18 years old from Beijing Chaoyang Hospital were selected in the study. They were divided into normal, overweight and obesity group according to BMI. The correlation between UA and BMI, triglyceride (TG) and other metabolic indicators were analyzed. Logistic regression was used to analyze the risk factors for hyperuricemia. Results UA in the subjects increased with the increasing of BMI and the difference in BMI groups was statistically significant. UA was significantly positively correlated with BMI, TG, fasting insulin (FINS), and homeostasis model assessment insulin resistance index (HOMA-IR). Male (OR=3.02), overweight and obesity (OR=1.51 and 2.59), higher TG (OR=1.62) and raised low-density lipoprotein cholesterol (LDL-C, OR=2.23) were risk factors for hyperuricemia (all P<0.05). Conclusions UA is significantly positively correlated with BMI, TG, FINS and HOMA-IR. Male, overweight and obesity, the high TG and the high LDL-C are risk factors for hyperuricemia. Key words: Body mass index; Uric acid; Hyperuricemia