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The antagonism function of PUFA to embryotoxicity in high iodine group

李英华, 朱惠民, 许丽辉, 尹桂山, 赵京山, 王桂香

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Abstract

Objective To observe the antagonism function of polyunsaturated fatty acid(PUFA) on embryotoxicity in high iodine group.Methods The mouse were divided into there groups,middle iodine group,high iodine group and high iodine added DHA+EPA group.The mouse in middle iodine group drank 50 μg/L iodine ion water,the others drank 3000 μg/L iodine ion water.After 3 months,the mouse mated.The development of the embryo were observed.Results The absolute weight and relative weight of goiter in high iodine added DHA+EPA group were lower than that in high iodine group (P<0.01).The teratogeny rate and abnormal neckbones were lower too (P<0.05).But the mean body weight and placenta were higher than that in high iodine ion group (P<0.05).The mean placenta weight were higher than that in middle iodine group and the other indicators have no statistic difference.Conclusions DHA+EPA protects the fetation in high iodine group.

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What this paper is about

Objective To observe the antagonism function of polyunsaturated fatty acid(PUFA) on embryotoxicity in high iodine group.Methods The mouse were divided into there groups,middle iodine group,high iodine group and high iodine added DHA+EPA group.The mouse in middle iodine group drank 50 μg/L iodine ion water,the others drank 3000 μg/L iodine ion water.After 3 months,the mouse mated.The development of the embryo were observed.Results The absolute weight and relative weight of goiter in high iodine added DHA+EPA group were lower than that in high iodine group (P<0.01).The teratogeny rate and abnormal neckbones were lower too (P<0.05).But the mean body weight and placenta were higher than that in high iodine ion group (P<0.05).The mean placenta weight were higher than that in middle iodine group and the other indicators have no statistic difference.Conclusions DHA+EPA protects the fetation in high iodine group.

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Available abstract

Objective To observe the antagonism function of polyunsaturated fatty acid(PUFA) on embryotoxicity in high iodine group.Methods The mouse were divided into there groups,middle iodine group,high iodine group and high iodine added DHA+EPA group.The mouse in middle iodine group drank 50 μg/L iodine ion water,the others drank 3000 μg/L iodine ion water.After 3 months,the mouse mated.The development of the embryo were observed.Results The absolute weight and relative weight of goiter in high iodine added DHA+EPA group were lower than that in high iodine group (P<0.01).The teratogeny rate and abnormal neckbones were lower too (P<0.05).But the mean body weight and placenta were higher than that in high iodine ion group (P<0.05).The mean placenta weight were higher than that in middle iodine group and the other indicators have no statistic difference.Conclusions DHA+EPA protects the fetation in high iodine group.

Key concepts: Iodine, Chemistry, Polyunsaturated fatty acid, Internal medicine, Endocrinology, Fatty acid, Biochemistry, Medicine

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