Effect of excess iodine on function of thyroid in progeny of mice and intervention of selenium

Objective To study the influence of excess iodine intake on function and morphology of thryoid in progeny of mice and intervention of selenium.Methods 60 Balb/c mice were divided randomly into four groups:control group,excess iodine group(3?000?μg/L I),supplement selenium group(200?μg/L Se)and excess iodine plus selenium(200?μg/L Se)group.The mice were given drinking water including some dosage of iodine or selenium.At the end of the fourth month,urinary iodine was determined and then the mice were mated.Results On the postnatal day 14,the mice in excess iodine group showed coloid goiter,serum TT_4 level was lower significantly and serum TSH level was higher in excess iodine group than control group and excess iodine plus selenium.On postnatal day 28,no significance was found in serum TT_4,TT_3 and TSH level between four groups.Conclusion excess iodine intake may damage the function and morphology of thyroid in progent of mice and selenium supplementation exerted favorable effects on it.