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Relationship Between Angiotensin Converting Enzyme Gene Polymorphism,Angiotensin Converting Enzyme Activity And Coronary Heart Disease

刘华欣, 曹丽春, 廖淑梅, 王吉伟, 傅桂莲

Abstract

目的研究血管紧张素转换酶(ACE)基因多态性、血管紧张素转换酶活性与冠心病的相关关系.方法应用聚合酶链式反应(PCR)检测ACE基因第16内含子I/D多态性,并计算基因型和等位基因频率.应用酶偶联速率法检测血清血管紧张素转换酶活性.结果在51例冠心组中ACE基因DD基因型和D等位基因频率分别是35%和61%,ACE平均活性为350.3±91.1,在83例正常对照组中的ACE基因DD 基因型和D等位基因频率分别是16%和45%,ACE平均活性为286.7±79.6,两者相比具有显著性差异.结论 ACE D等位基因可能是冠心病潜在的危险因素之一,而高活性的ACE对冠心病的发生发展有着重要的作用.

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Key concepts: Angiotensin-converting enzyme, Enzyme, Internal medicine, Renin–angiotensin system, Gene, Gene polymorphism, Coronary heart disease, Polymorphism (computer science)