The distribution of angiotensin converting enzyme gene I/D polymorphism and its relationship with essential hypertension
刘长云, 周建光, 黄亚莉, 方以群
Abstract
刘长云, 周建光, 黄亚莉, 方以群
Abstract
目的 研究血管紧张素转换酶(angiotensis converting enzyme,ACE)基因I/D多态性的分布及其与高血压发病之间的关系.方法 应用PCR方法对356例海军干休所离退休干部进行ACE I/D基因型检测,并分析比较.结果 海军老干部高血压病组ACE Ⅱ和ID基因型显著低于对照组(P<0.01),而DD基因型显著高于对照组(P<0.01).结论 海军老干部ACE基因多态性与原发性高血压有关,DD基因型易患高血压。
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目的 研究血管紧张素转换酶(angiotensis converting enzyme,ACE)基因I/D多态性的分布及其与高血压发病之间的关系.方法 应用PCR方法对356例海军干休所离退休干部进行ACE I/D基因型检测,并分析比较.结果 海军老干部高血压病组ACE Ⅱ和ID基因型显著低于对照组(P<0.01),而DD基因型显著高于对照组(P<0.01).结论 海军老干部ACE基因多态性与原发性高血压有关,DD基因型易患高血压。
Key concepts: Gene, Genetics, Essential hypertension, Polymorphism (computer science), Angiotensin-converting enzyme, Distribution (mathematics), Biology, Internal medicine