Influence of combination therapy of lamivudine and IFN on IL-8 level in chronic hepatitis B patients

Objective To explore the influence of combination therapy of IFN and lamivudine on IL-8 level in chronic hepatitis B patients.Methods 58 patients with chronic hepatitis B were selected and divided into control group and experiment group randomly and evenly.Based on regular treatments,control group received treatment of lamivudine and experiment group received combination treatment of lamivudine and IFN alpha-1 b.Restoring rate of ALT,serum conversion rate of HBeAg/anti-HBe,conversion rate of HBV-DNA and mutation rate of YMDD were observed and compared between two groups.Serum level of IL-8 was observed before and after treatment in two groups.Results Compared with control group,serum conversion rate of HBeAg/anti-HBe significantly increased,mutation rate of YMDD significantly decreased in experiment group(P ＜ 0.05).Serum level of IL-8 in two groups significantly decreased after treatment,but more significant in experiment group compared with control group (P ＜ 0.05).Conclusion Combination therapy of lamivudine and IFN shows positive effects to chronic hepatitis B,mainly via inhibiting activities of HBV and decreasing status of inflammation. Key words: Hepatitis, B Chronic ;  IFN ;  Lamivudine;  Interleukin