Study on the pulmonary protective effect of dexmedetomidine in ophthalmic surgery

Objective To investigate whether dexmedetomidine intravenous injection has protective effects on ventilator-associated lung injury (VILI). Methods The children with bilateral strabismus who underwent selective strabismus correction in Cangzhou Central Hospital were selected as the study subjects.They were randomly divided into two groups: dexmedetomidine group (group D), and control group (group P), 30 cases in each group.Before the induction of anesthesia, the infusion of dexmedetomidine in the D group was 0.5 μg/kg for 15 min, Then pumped at 0.05 μg·kg-1·min-1 to half an hour before the end of the procedure.Group P was given the same volume of physiological saline.The two groups of patients received 3 ml of radial artery blood samples after induction of anesthesia (T1), 30 minutes after the start of surgery (T2), and 6 hours after surgery (T4). The concentrations of plasma tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and IL-8 were determined by enzyme-linked immunosorbent assay in 2 ml.1 ml for blood gas analysis.We recorded arterial oxygen partial pressure (PaO2) and carbon dioxide partial pressure (PaCO2), and calculated the pulmonary oxygenation index (OI) and respiratory index (RI). Results Compared with group P, the levels of TNF-α, IL-6 and IL-8 were decreased in group D at T2 and T3, OI increased, RI decreased (P 0.05). Conclusions Dexmedetomidine inhibits the release of inflammatory factors and improves lung function to achieve lung protection, lung injury caused by short-term mechanical ventilation is transient, regardless of whether dexmedetomidine was used or not, inflammatory factors and lung function returned to preoperative levels 6 h after surgery. Key words: Lung injury; Ventilator, mechanical; Strabismus; Dexmedetomidine