Protective effect of dexmedetomidine on lung injury after cardiac surgery under cardiopulmonary bypass

Objective To research the protective effect of dexmedetomidine on lung injury after cardiac surgery under cardiopulmonary bypass. Methods 60 cases of cardiac surgery patients in our hospital were selected and randomly divided into two groups,each 30 cases. The observation group was given 0. 7 μg /( kgoh) dexmedetomidine after anesthesia at the end of surgery,and the control group was not given any treatment. The levels of TNF-α,IL-1β and IL-6 and alveolar-arterial oxygen difference( Aa DO2),oxygenation index( OI),respiratory index( RI) of the two groups were detected at T0( before administration),T1( before CPB),T2( after the shutdown 1h),T3( after stopping 4h),and T4( after stopping 24h). Results The levels of TNF-α,IL-1β and IL-6 of the two groups at T1~ T4 point showed a decreasing trend after the first increases,and the difference was statistically significant at each point( P 0. 05). The levels of TNF-α,IL-1β and IL-6 were significantly lower in the observation group than in the control group( P 0. 05). The value of Aa DO2 and RI of the two groups at T1~ T3 showed a increasing trend( P 0. 05),and the value of OI of the two groups at T1~ T3 showed a decreasing trend. The values of Aa DO2,OI and RI were significantly lower in the observation group than in the control group( P 0. 05). Conclusion Dexmedetomidine can effectively inhibit inflammation and repair lung injury of heart surgery patients with cardiopulmonary bypass.