2016•International journal of pediatricsRequires access

Progress in male sex determination and differentiation

Qingxu Liu

Abstract

Sex determination and differentiation mean the process that the bipotential gonads develop into ovaries or testes.There are many genes involved in male's sex determination and differentiation.The changes of the regulating genes may lead to disorders of sex development.Sex-determining region Y(SRY)gene was the first discovered gene related to abnormal sexual development.Serval studies have found that SRY-related HMG box 9(SOX9)and fibroblast growth factor 9(FGF9)are associated with disorders of sex development in recent years.This article aims to provide an review of recent study of the role of SRY, SOX9 and FGF9 in sex determination and differentiation.It will provide a foundation for diagnosis and treatment of genetic disease related with male's sex determination and differentiation. Key words: Disorders of sex development; Gene; Disease

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Key concepts: Testis determining factor, Sexual differentiation, SOX9, Medicine, FGF9, Gene, Physiology, Genetics