Expression and clinical significance of S100A11 in non-small cell lung cancer

Objective To investigate the expression of S100A11 protein in non-small cell lung cancer (NSCLC) and its association with clinical and pathological characteristics. Methods The expressions of S100A11 protein in 112 NSCLC tumor tissues (group A), tumor-adjacent tissues (group B) and 10 normal lung tissues (group C) were detected by immunohistochemical SP method. The association of S100A11 expre-ssion with clinical pathological characteristics was analyzed. Results The percentage of the cases with high expression cases of S100A11 protein was 78.6% (88/112), and the low expression rate was 21.4 % (24/112) in group A. The low expression rate of S100A11 protein was 100.0% (112/112) in group B. The negative expression rate of S100A11 protein was 100.0% (10/10) in group C. The difference of S100A11 expression among the three groups was statistically significant (χ2=153.634, P<0.001). The S100A11 expression was associated with pathological type (χ2=6.807, P=0.009), differentiated degree (χ2=5.029, P=0.025), regional lymph node metastasis (χ2=11.721, P=0.001) in NSCLC, but it was not associated with gender (χ2=0.020, P=0.888), age (χ2=0.816, P=0.366) and tumor size (χ2=0.406, P=0.524). Conclusion S100A11 is highly expressed in NSCLC, which is closely related with biological behavioral cha-racteristics. S100A11 may participate in the occurrence and development of NSCLC, and it is expected to become the potential target of diagnosis and prognosis in patients with NSCLC. Key words: Carcinoma, non-small-cell lung; Immunohistochemistry; S100A11