2003中国行为医学科学Requires access

Study on the effect of sucralfate with doxepinum on the praxiological change of the psychological stress rats and their protective effect on gastric mucosa

胡慧, 吴先哲

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Abstract

目的比较硫糖铝和多虑平对心理应激大鼠行为的影响及对胃粘膜的保护作用.方法 (1)刺激6-OHDA-treated大鼠攻击受试大鼠作为心理应激源.(2)采用高架十字迷宫、开放场地试验检测受试大鼠行为学的改变.(3)胃粘膜损伤指数和组织学评价确定硫糖铝和多虑平对心理应激大鼠胃粘膜的保护作用.结果 (1)强烈的心理应激可导致大鼠胃粘膜损伤.(2)硫糖铝和多虑平可减轻大鼠胃粘膜损伤程度.(3)多虑平可减轻心理应激大鼠情绪和行为的改变.结论尽管多虑平能调适大鼠抗心理应激能力,但硫糖铝仍表现出更好的胃粘膜保护作用.

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目的比较硫糖铝和多虑平对心理应激大鼠行为的影响及对胃粘膜的保护作用.方法 (1)刺激6-OHDA-treated大鼠攻击受试大鼠作为心理应激源.(2)采用高架十字迷宫、开放场地试验检测受试大鼠行为学的改变.(3)胃粘膜损伤指数和组织学评价确定硫糖铝和多虑平对心理应激大鼠胃粘膜的保护作用.结果 (1)强烈的心理应激可导致大鼠胃粘膜损伤.(2)硫糖铝和多虑平可减轻大鼠胃粘膜损伤程度.(3)多虑平可减轻心理应激大鼠情绪和行为的改变.结论尽管多虑平能调适大鼠抗心理应激能力,但硫糖铝仍表现出更好的胃粘膜保护作用.

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Available abstract

目的比较硫糖铝和多虑平对心理应激大鼠行为的影响及对胃粘膜的保护作用.方法 (1)刺激6-OHDA-treated大鼠攻击受试大鼠作为心理应激源.(2)采用高架十字迷宫、开放场地试验检测受试大鼠行为学的改变.(3)胃粘膜损伤指数和组织学评价确定硫糖铝和多虑平对心理应激大鼠胃粘膜的保护作用.结果 (1)强烈的心理应激可导致大鼠胃粘膜损伤.(2)硫糖铝和多虑平可减轻大鼠胃粘膜损伤程度.(3)多虑平可减轻心理应激大鼠情绪和行为的改变.结论尽管多虑平能调适大鼠抗心理应激能力,但硫糖铝仍表现出更好的胃粘膜保护作用.

Key concepts: Sucralfate, Gastric mucosa, Psychological stress, Psychology, Stress (linguistics), Clinical psychology, Social psychology, Medicine

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