Efficacy of combined treatment for neovascular glaucoma

Objective To evaluate the efficacy of combined treatment for neovascular glaucoma(NVG). Methods Forty-nine eyes of 48 patients with NVG were treated with intravitreal Conbercept 0.5 mg (0.05 ml) injection firstly and panretinal photocoagulation (PRP) 3-7days after injection. Then they underwent compound trabeculectomy combined with mitomycin C or the Ex-press implantation. Patients with cataract underwent phacoemulsification combined Ex-press implantation. Vitrectomy and PRP was performed for patients combined with vitreous hemorrhage.Iris neovascularization condition, the intraocular pressure, visual acuity and complications after surgery were recorded.The followed-up time was 6 months. Results The new vessels of iris and anterior chamber angle were completely regressed 3-5 days after intravitreal injection of Conbercept in 49 eyes.Visual acuity at the last follow-up time improved in 18 eyes(36.7%), unchanged in 31 eyes(63.3%). The pre-surgery IOP was (42.60±6.12) mmHg (1 mmHg=0.133 kPa), the postoperative IOP was (15.26±4.70)mmHg.Successful rate of surgery was 77.6%(38/49). Eleven eyes were partially successful. No recurrence of neovascularization happened. Conclusion According to different clinical characteristics of neovascular glaucoma, the individualized combined treatment is chose. Key words: Glaucoma, neovascular; Conbercept; Trabeculectomy, compound; Implantation, Ex-press