Investigation of pyridinolne cross linked carboxyterminal telopeptide of type I collagen on carcinomaofrectum

Objective To investigate the clinical usefulness of determination of serum pyridinoline cross linked carboxyterminal telopeptide of type Ⅰ collagen (ICTP) in patients with carcinomaofrectum.Methods 75 malignant carcinomaofrectum patients in group A with 71 primary malignant carcinomaofrecrum patients and 4 metastatic carcinomaofrectum patients were analyzed,43 benign carcinomaofrectum patients were including group B,52 normal persons were chosen in group C,Serum ICTP in everybody was determined by enzyme immunoassay (EIA).Results The serum level of ICTP in group A was (14.84 ±8.49) μg/L,and the serum level of primary malignant carcinomaofrectum,and metastatic tumor of bone in group A were (17.47 ± 10.86) μg/L and (8.14 ± 5.45) μg/L,the serum level of ICTP in group B and C were (6.75 ±3.34) μg/L and (4.68 ±2.91) μg/L.The serum level in group A was significantly higher than that in group B and C (P ＜ 0.05),At the same time,the serum level in primary malignant carcinomaofrectum patients were significantly higher than that of metastatic carcinomaofrectum patients (P ＜ 0.05).Conclusion Serum ICTP was a sensitive and convenient biochemical index which could diagnose and identify carcinomaofrectum. Key words: Benign carcinomaofrectum ;  Primary carcinomaofrectum;  Metastatic tumor;  Pyridinoline cross linked carboxyterminal telopeptide of type Ⅰ collagen