Application of pyridinoline cross-linked carboxyterminal telopeptide of Type I Collagen on primary Bone Tumor

Objective To explore the clinical usefulness of determination of serum pyridinoline cross-linked carboxyterminal telopeptide of Type I Collagen(ICTP) in patients with primary malignant bone tumor and benign bone tumor.Methods Serum ICTP in 42 malignant bone tumor patients and 34 benign bone tumor patients were analyzed.Serum ICTP was determined by enzyme immunoassay(EIA).Results The serum level of ICTP shown(16.91±10.73) μg/L in malignant bone tumor group was significantly higher than those of the control group(P0.01).The srum level(5.70±4.40) μg/L in benign bone tumor group has no significantly statistics compared with the control group(P0.05).At the same time,the serum level in malignant bone tumor group were significantly higher than that of benign bone tumor group(P0.01).Conclusion Serum ICTP was a sensitive and convenient biochemical index which could diagnose and identify primary bone tumor.