Correlation study of serum uric acid and insulin resistance in type 2 diabetes patients with non-alcoholic fatty liver disease

Objective To investigate the correlation and clinical significance between serum uric acid(SUA) levels and insulin resistance in type 2 diabetes(T2DM) with non-alcoholic fatty liver disease(NAFLD). Methods There were 54 T2DM patients with NAFLD in combined group, 50 cases in simple T2DM group and 37 cases in healthy group.The clinical parameters, SUA and insulin resistance(IR) levels were determined and compared among the three groups.The correlations among NAFLD, SUA levels and IR were analyzed. Results The SUA levels and IR index(HOMA-IR) of the combined group were higher than those of the other two groups(SUA: F=9.77, P=0.00; IR: H=122.13, P=0.00). The studies showed that NAFLD was positively correlated with SUA, TG, HOMA-IR(r=0.323, P=0.00; r=0.294, P=0.00; r=0.331, P=0.00). Logistic regression analysis revealed that IR, SUA and TG were the risk factors for T2DM with NAFLD(B=0.852, 0.012, 0.707). Conclusion The increase of SUA is independent risk factor for T2DM with NAFLD, so to control SUA and improve insulin sensitivity can help to prevent the development of T2DM with NAFLD. Key words: Diabetes mellitus, type 2; Fatty liver; Uric acid; Insulin resistance