2011•Zhonghua chuangshang zazhiRequires access

Cognitive function changes in response to expression of glucocorticoid recepmr from rat hippocampus after traumatic brain injury

Wei Gao, Xiaosheng He, Xiang Zhang, Zhou Fei, Hongyu Xu, Junli Huo, Xiaohong Chen

Abstract

Objective To explore the effect of glucocorticoid receptor(GR)expression in rat hippocampus on cognitive function after traumatic brain injury(TBI). Methods The TBI model wag established in rats.Then,immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitire dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI.Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction. Key words: Brain injuries; Hippocampus; Receptors,gucocortiocid; Cognitive dysfunction

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Key concepts: Morris water navigation task, Hippocampus, Hippocampal formation, Medicine, Traumatic brain injury, Glucocorticoid receptor, Glucocorticoid, Western blot