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2011•Chinese Journal of Neurosurgical Disease ResearchRequires access

Expression of glucocorticoid receptor mRNA in rat hippocampus after traumatic brain injury

Hongyu Xu

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Abstract

Objective To explore the expression of glucocorticoid receptor(GR) mRNA in rat hippocampus and its effect on cognitive function after traumatic brain injury(TBI).Methods The rat TBI model by lateral acceleration rotation of head was established.GR mRNA levels were detected by reverse transcription polymerase chain reaction(RT-PCR),and cognitive function was evaluated by Morris water maze.Results Expression of GR mRNA in rat hippocampus remained in low level from 4 d to 7 d after TBI.Morris water maze test showed significant impairment of cognitive functions in rats.Conclusion Down-regulation of GR mRNA in hippocampus induces the cognitive dysfunction in rats.

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Objective To explore the expression of glucocorticoid receptor(GR) mRNA in rat hippocampus and its effect on cognitive function after traumatic brain injury(TBI).Methods The rat TBI model by lateral acceleration rotation of head was established.GR mRNA levels were detected by reverse transcription polymerase chain reaction(RT-PCR),and cognitive function was evaluated by Morris water maze.Results Expression of GR mRNA in rat hippocampus remained in low level from 4 d to 7 d after TBI.Morris water maze test showed significant impairment of cognitive functions in rats.Conclusion Down-regulation of GR mRNA in hippocampus induces the cognitive dysfunction in rats.

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Available abstract

Objective To explore the expression of glucocorticoid receptor(GR) mRNA in rat hippocampus and its effect on cognitive function after traumatic brain injury(TBI).Methods The rat TBI model by lateral acceleration rotation of head was established.GR mRNA levels were detected by reverse transcription polymerase chain reaction(RT-PCR),and cognitive function was evaluated by Morris water maze.Results Expression of GR mRNA in rat hippocampus remained in low level from 4 d to 7 d after TBI.Morris water maze test showed significant impairment of cognitive functions in rats.Conclusion Down-regulation of GR mRNA in hippocampus induces the cognitive dysfunction in rats.

Key concepts: Morris water navigation task, Hippocampus, Traumatic brain injury, Glucocorticoid receptor, Messenger RNA, Internal medicine, Endocrinology, Glucocorticoid

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