2009•Int J ImmunolRequires access

Function and expression of chemokiue CCL28

Xue Liu, Guang‐Shui Jiang

Abstract

CCL28 is a novel cysteine-cysteine (CC) chemokine, which is selectively expressed by epithelial cells in diverse mucosal tissues. The receptors of this chemokine are CCRIO and CCR3. By binding CCR10 or CCR3, CCL28 recruits CD4+T cells, CD8+T cells and IgA ASC(antibody-secreting cell) from blood to relat-ed tissues. Furthermore, CCL28 has potent antimierobisl activity. Therefore, CCL28 may play important roles in mucosal and tumor immunity. The expression of CCL28 may be influenced by several exterior and interior factors. Investigation on its expression regulation may set light on exploring a new way for the prevention and treatment of related diseases. Key words: CCL28; Chemokine; IgA+ASC; CCR10; CCR3

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Key concepts: CCR10, CCR3, Chemokine receptor, C-C chemokine receptor type 6, CC chemokine receptors, Chemokine, Immunology, Cell biology