Expression and significance of Pokemon in human pituitary adenoma

Objective To investigate the expression of oncogene Pokemon in human pituitary adenomas (PAs) tissues.Methods Immunohistochemistry was applied to detect the expression of Pokemon protein in 35 cases of PAs tissues and 4 cases of normal pituitary tissues.Results Pokemon was over expressed in 35 cases of Pas tissues as compared with 4 cases of normal pituitary tissues (P ＜ 0.05),and it mainly located in the nuclei of PAs ceils.No significant difference (P ＞ 0.05) was found in the Pokemon expression between the immunohistochemical classifications in PAs.Conclusion The over-expression of Pokemon is likely to play an important part in pathogenesis of pituitary adenoma. Key words: Pokemon;  Pituitary adenoma;  Immunohistochemistry