Effects of mesalazine combined with bifico on the treatment of ulcerative colitis and on TLR4 and MyD88

Objective To investigate the clinical efficacy of mesalazine combined with bifico in the treatment of ulcerative co -litis （UC） and its effect on toll-like receptor 4 （TLR4） and myeloid differentiation factor 88 （MyD88）.Methods A total of 86 cases of UC was randomly divided into the observation and control groups with 43 cases in each group .The observation group was given me-salazine combined bifico treatment , and the control group was given mesalazine , and eight weeks as a course of treatment .The clinical efficacy was observed .Serum TLR4 and MyD88 were tested.Adverse reaction in treatment was recorded .Results The total effective rate （95.35%） in observation group was significantly higher than that （81.40%） in control group（ P 0.05 ） .Conclusions Mesalazine combined with bifico in the treatment of UC is safe and effective . The effect may be related to regulation of peripheral blood TLR 4 and MyD88 content . Key words: Colitis,ulcerative/drug therapy; Mesalamine/therapeutic use; Probiotics/therapeutic use; Toll-like receptor 4/blood; Myeloid differentiation factor 88/blood