2015•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Effect of sulfasalazine and mesalazine on TLR4, NF-κb expression in intestinal mucosa of patients with ulcerative colitis
Zhou Quan-ku
Open publisher page 0 citations
Abstract
【Objective】To study the effects of sulfasalazine and mesalazine on TLR4, NF-κb expression in intestinal mucosa of patients with ulcerative colitis.【Methods】Ulcerative colitis patients received mesalazine therapy were enrolled in observation group, the patients received sulfasalazine in the same period were enrolled in control group. The clinical symptoms, intestinal mucosal score were compared and m RNA levels of TLR4, NF-κb were detected by real-time PCR.【Results】The abdominal pain, diarrhea, pus and blood stool, mucosal score of patients in observation group were lower than that in control group. After treatment, the m RNA levels of TLR-4, NF-κb were lower than those before treatment. The levels of TLR-4 m RNA and NF-κb m RNA in observation group were significantly lower than that in control group(P 0.05). The m RNA levels of TLR4, NF-κb were positively correlated with abdominal pain, diarrhea, pus and blood stool, mucosal score(P 0.05).【Conclusion】Mesalazine could effectively improve clinical symptoms and intestinal mucosa condition, and it might play a role through inhibiting expression of TLR4, NF-κb in intestinal mucosa.