2008•Zhonghua shiyan yanke zazhiRequires access

Small interference RNA and corneal neovascularization

左磊, 许迅, 王丰

Abstract

角膜病是一类严重的致盲眼病,而角膜新生血管(CNV)是角膜化学伤、外伤、感染等多种疾病的共同病理改变.导致CNV形成的原因仍不明确.血管内皮生长因子(VEGF)可能是CNV形成中最主要的血管形成因子.CNV的治疗方法包括药物、手术和激光等,但效果均不理想.RNA干扰技术给CNV机制研究和治疗带来新的思路.使用siRNA针对恰当的基因靶点产生沉默效应,是治疗CNV的潜在有效途径。

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Available abstract

Key concepts: Corneal neovascularization, Ophthalmology, Interference (communication), RNA interference, Optometry, Medicine, Chemistry, RNA