Clinical significance and expression of CD146 on peripheral blood cells in patients with chronic renal failure

Objective To study the clinical significance and expression of CD146 on peripheral blood cells in patients with chronic renal failure (CRF). Methods Expression of CD146 in peripheral blood samples from 51 ambulatory or hospitalized patients with CRF (registered between August 2007 and July 2009 to our hospital) and from 33 normal controls were determined and compared between two groups. Correlation of peripheral blood CD146 with blood urea nitrogen (BUN) , and serum creatinine (Scr) in patients with CRF was analyzed. Results Compared with normal controls, the rate of CD146* on monocyte and neutrophile in patients with CRF were significantly higher [ (4.09±3.48)% vs (0.20±0.10)% ;(4.71± 3.94)% vs (0.79±0.14)% , both P<0.001], and the number of CD45-CD146* cells in patients with CRF was obviously higher [ (16.43±10.48) /μl vs (2.16±0.81 )/μl,P<0.001) ]. The number of CD45-CD146+ cells in patients with CRF was positively correlated with BUN and Scr (r=0.480 and 0.595, both P<0.01). Conclusions Correlation between increased CD 146 on monocyte or neutrophile and the pathogenesis of CRF is found. The increase in CD45-CD146+ cell numbers is correlated with the pathogenesis and severity of CRF. Key words: Kidney failure, chronic; Antigens, CD146; Blood urea nitrogen; Blood creatinine; Peripheral blood