Adjustment of thymic peptide on immunologic derangement in chronic kidney disease

Objective:To study the adjustment of thymic peptide on T lymphocyte subset and the activity of nat-ural killer cell of peripheral blood in patients with chronic kidney disease.Methods:The study included23normal control(controls group)and34patients with chronic kidney disease(CKD group)who received intervenous drop in-fusion treatment with thymic peptide50mg plus normal sodium100ml every day,four weeks in all.T lymphocyte subset(CD4,CD8,CD4/CD8),the activity of natural killer cell(NK),serum blood total protein(TP),albumin(Al),blood urea nitrogen(BUN),serum creatinine(Scr),complement(C3,C4)and immunoglobulin(IgG)of peripheral blood were observed in control group and CKD group before and after the four weeks observation,and then analyzed with satistics.Results:In CKD group,CD4was positively correlated with CD4/CD8(P0.01)and NK(P0.05);CD8was negatively correlated with CD4/CD8(P0.01);The same was IgG with TP,Al(allP0.01)and NK(P0.05),C3with C4(P0.01)and CD4/CD8(P0.05).But CD8was negatively correlated with CD4/CD8(P0.01).Before treatment,CD4/CD8,IgG,TP,Al,C3(allP0.01)and NK(P0.05)in CKD group were all lower but CD8was higher than those of normal group,there was significant deviation between two groups.CD4was lower than thatof normal group and was no significant deviation between two groups (P 0.05). After four weeks treatment, CD4, NK, Al(all P 0.01) and TP (P 0.05) were increased than that of before treatment, while significant deviation between the two. The same were CD4/CD8, CD8, C3, C4 and IgG, while no significant difference between the two (P 0.05). Conclusions: Immunologic derangement of cell immunity and humoral immune function is presented in CKD patients. Thymic peptide is effective to immunologic derangement through adjustment the levels of CD4, NK, TP, Al and can provide positive action in CKD patients.