The effect of artificial dermis and antologous platelet gel for children suffered from burn

Objective To observe the residual burn wounds of children treated with artificial dermis and antologous platelet gel （APG） after immersion bath at late post-burn stage. Methods Fifty-six children with residual wounds at late post-burn stage were enrolled in the study and randomly allocated into A（n = 28,experimental） and B（n = 28, control） groups. After treatment with immersion bath, the wounds in group A were treated with semi-exposure method. The wounds were covered with artificial dermis in suitable shape and spray APG twice a day, the artificial dermis was changed every 2 day or every 3 days after immersion bath. To compare the treatment effect, the wounds in group B were only treated with a dressing of monolayer gauze wetted with povidone iodine. The clinical outcomes, bacteriological findings and associated safety parameters were compared between two groups on 10 days after treatment. Results The wound healing rate, efficacy and the bacterial clearance rate in A group were 64. 3 %, 89. 3 % and 92. 3 %, respectively, and they were significantly higher than those in B group（32. 1 %, 67. 9% and 72. 0% ,respectively, P〈0.01）. No adverse side-effect was noted in either group. Conclusions Application of artificial dermis and APG after immersion bath is safe and effective for the elimination of residual wounds at late post-burn stage, which is beneficial to control wound infection and promote the wound healing. Key words: Burns;  Biological dressings;  Bacterial infections