Neuroprotective mechanisms of ischemic preconditioning： caspases and neuronal apoptosis

Ischemic preconditioning may mobilize self-protective mechanisms to induce endogenous neuroprotection through a variety of ways. It has potential clinical application value. Anti-apoptosis is an important part in the protective mechanisms of ischemic preconditioning~ Caspase family is the key molecule during the apoptotic execution process. It plays an important role in the neuronal apoptosis after cerebral ischemia. This article reviews the ischemic preconditioning-induced neuroprotective mechanisms and the roles of caspase family in neuronal apoptosis after cerebral ischemia. Key words: Brain Ischemia;  Ischemic Preconditioning;  Caspases;  Apoptosis