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The effect of nerve growth factor on neuron-specific enolase after hypoxic-ischemic brain damage in neonatal rats

胡勇, 邬建荣, 孔元原, 俞海国, 汤云珍

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Abstract

目的研究神经生长因子(NGF)对新生大鼠缺氧缺血性脑损伤(HIBD)的作用.方法应用新生7日龄SD大鼠制备HIBD模型,于缺氧缺血(HI)后即刻腹腔注射NGF 100 U/只或等量生理盐水,用放射免疫法测定缺氧缺血后24、48 h血清神经元特异性烯醇化酶(NSE)水平,用免疫组化法检测脑组织NSE蛋白表达变化.结果 NGF可降低血清NSE,增加左侧(缺血侧)脑组织中NSE蛋白水平表达.结论腹腔注射NGF对HIBD具有保护作用.

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What this paper is about

目的研究神经生长因子(NGF)对新生大鼠缺氧缺血性脑损伤(HIBD)的作用.方法应用新生7日龄SD大鼠制备HIBD模型,于缺氧缺血(HI)后即刻腹腔注射NGF 100 U/只或等量生理盐水,用放射免疫法测定缺氧缺血后24、48 h血清神经元特异性烯醇化酶(NSE)水平,用免疫组化法检测脑组织NSE蛋白表达变化.结果 NGF可降低血清NSE,增加左侧(缺血侧)脑组织中NSE蛋白水平表达.结论腹腔注射NGF对HIBD具有保护作用.

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Available abstract

目的研究神经生长因子(NGF)对新生大鼠缺氧缺血性脑损伤(HIBD)的作用.方法应用新生7日龄SD大鼠制备HIBD模型,于缺氧缺血(HI)后即刻腹腔注射NGF 100 U/只或等量生理盐水,用放射免疫法测定缺氧缺血后24、48 h血清神经元特异性烯醇化酶(NSE)水平,用免疫组化法检测脑组织NSE蛋白表达变化.结果 NGF可降低血清NSE,增加左侧(缺血侧)脑组织中NSE蛋白水平表达.结论腹腔注射NGF对HIBD具有保护作用.

Key concepts: Enolase, Nerve growth factor, Medicine, Brain damage, Neuron, Neuroscience, Internal medicine, Anesthesia

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The effect of nerve growth factor on neuron-specific enolase after hypoxic-ischemic brain damage in neonatal rats — Research Paper | ScholarLens