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The effect of nerve growth factor on neuron-specific enolase after hypoxic-ischemic brain damage in neonatal rats

Yuanyuan Kong

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Abstract

Objective To expore the effect of nerve growth factor(NGF) on hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods The HIBD models were established with 7-day postnatal SD rats.Right after hypoxic-ischemic insult,NGF 100U per rat or normal saline solution was injected intraperisoneally.At 24 hours and 48 hours after hypoxic-ischemic insult,values of neuron-specific enolase(NSE)in serum were measured by radioimmunoassy and immunohistochemical technique was used to investigate the changes of expression of NSE in cerebral tissues. Results The use of NGF lowered serum NSE and increased the protein expression of NSE in the left cerebral tissues. Conclusion It is suggested that intraperitoneal administration on NGF can protect against hypoxic-ischemic brain damage(HIBD) in neonatal rats.

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Objective To expore the effect of nerve growth factor(NGF) on hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods The HIBD models were established with 7-day postnatal SD rats.Right after hypoxic-ischemic insult,NGF 100U per rat or normal saline solution was injected intraperisoneally.At 24 hours and 48 hours after hypoxic-ischemic insult,values of neuron-specific enolase(NSE)in serum were measured by radioimmunoassy and immunohistochemical technique was used to investigate the changes of expression of NSE in cerebral tissues. Results The use of NGF lowered serum NSE and increased the protein expression of NSE in the left cerebral tissues. Conclusion It is suggested that intraperitoneal administration on NGF can protect against hypoxic-ischemic brain damage(HIBD) in neonatal rats.

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Available abstract

Objective To expore the effect of nerve growth factor(NGF) on hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods The HIBD models were established with 7-day postnatal SD rats.Right after hypoxic-ischemic insult,NGF 100U per rat or normal saline solution was injected intraperisoneally.At 24 hours and 48 hours after hypoxic-ischemic insult,values of neuron-specific enolase(NSE)in serum were measured by radioimmunoassy and immunohistochemical technique was used to investigate the changes of expression of NSE in cerebral tissues. Results The use of NGF lowered serum NSE and increased the protein expression of NSE in the left cerebral tissues. Conclusion It is suggested that intraperitoneal administration on NGF can protect against hypoxic-ischemic brain damage(HIBD) in neonatal rats.

Key concepts: Enolase, Nerve growth factor, Brain damage, Medicine, Immunohistochemistry, Saline, Endocrinology, Internal medicine

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The effect of nerve growth factor on neuron-specific enolase after hypoxic-ischemic brain damage in neonatal rats — Research Paper | ScholarLens