Effect of valsartan combined with sulodexide on diabetic nephropathy

Objective To observe the effect of the combined therapy of valsartan and sulodexide on diabetic nephropathy(DN).Methods Thirty-six patients with DN-Ⅲ stage and thirty-six patients with DN-Ⅳ stage were randomized divided into valsartan group,sulodexide group,valsartan and sulodexide group,each group had 12 patients.The follow-up was 12 weeks.Then the UAER,24 h urinary protein,serum creatinine,blood lipid,plasma albumin were measured.Results After treatment of 12 weeks,the level of UAER of DN-Ⅲ stage and 24 h urinary protein of DN-Ⅳ stage decreased significantly in all the three groups,and no significant difference was observed between valsartan group and sulodexide group(P ＞ 0.05)in the two stages,but significant difference was noted compared with combined therapy group(P ＜ 0.05).Conclusions Valsartan combined with sulodexide can effectively decrease the level of urine protein in patients with DN and the effect is better than single application. Key words: Diabetic nephropathy ;  Sulodexide ;  Valsartan