Relationship between different appearance and pathology change under gastroscope and Helicobacter pylori infection in chronic atrophic gastritis

Objective To investigate the relationship between different appearance and pathology change under gastroseope in chronic atrophic gastritis and Helicobacter pylori (Hp) infection. Method The performance of endoscopic morphology, Hp infection and pathology results of patients diagnosed as chronic atrophic gastritis by endoscopy were analyzed retrospectively in 1623 cases and the relationship between different gastroscope forms of change in chronic atrophic gastritis and Hp infection were investigated and the pathological diagnosis results were analyzed retrospectively. Results Four hundred and eighty-two eases were diagnosed as chronic atrophic gastritis in 1623 cases. Group A included 239 patients (endoscopic features were red and white to white-based mucosal, or even flattened folds disappeared, mucosal blood revealed), group B included 243 patients (endoscopic features were granular or nodular mucosa). In group A, 173 eases (72.4%) were diagnosed as atrophic gastritis. In group B, 206 eases (84.8%) were diagnosed as atrophic gastritis. The diagnosis accordance rate of the two groups had significant difference (P < 0.05). In group A, 24 cases (10.0%) showed intestinal metaplasia,and 25 cases( 10.5% ) showed atypical hyperplasia.In group B, 45 cases (18.5%) showed intestinal metaplasia ,and 57 cases (23.5%) showed atypical hyperplasia. The occurrence rates of intestinal metaplasia and atypical hyperplasia had significant difference between the two groups (P< 0.05). The Hp infection rate of group A and group B was 57.7% (138/239) and 72.8% (177/243) respectively, and there was significant difference (P <0.05). Conclusions The incidences of intestinal metaplasia, dysplasia and Hp infection in chronic atrophic gastritis with endoscopic mucosal rough as the main manifestation are higher than those in other forms of chronic atrophic gastritis.More attention should be paid to clinical diagnosis, treatment and follow-up. Key words: Gastritis,atrophic; Gastroseopy; Helicobacter pylori; Infection