A case-control study on pregnancy outcome of fetal reduction to single fetus from dizygotic twins after in vitro fertilization and intracytoplasmic sperm injections

Objective To discuss the pregnancy outcomes of reduction of biovular twin pregnancy. Methods The pregnancy outcomes including late abortion rate and premature delivery rate were compared among 102 cases of twin pregnancy underwent fetal reduction to singleton (group A), 75 cases of triplet pregnancy underwent fetal reduction to twin pregnancy (group B) in the early trimester of pregnancy and 4 638 cases of twin pregnancy did not accept fetal reduction (group C) after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) from January 2008 to December 2014. Results The rate of premature, delivery with low birth weight children were reduced significantly, gestational weeks were longer and birth weight was increased significantly in the group of early fetal reduction of biovular twin pregnancy, compared with that in the group of triplet pregnancy reduced to twin pregnancy and the group of twin pregnancy without fetal reduction, and the differences were statistically significant (P<0.05). The differences in the late abortion rate were not statistically significant. Conclusion For the biovular twin pregnancy, it was safe and got better pregnancy outcome to conduct fetal reduction in the early trimester. Key words: Multiple pregnancy; Twin pregnancy; Fetal reduction; Pregnancy outcome