Outcomes of Twin or Multiple Pregnancy After IVF-ET

Objective: To compare the outcome of pregnancy between twin pregnancy and singleton pregnancy after in vitro fertilization and embryo transfer(IVF-ET),and to evaluate the feasibility of fetal reduction in twin pregnancy after in IVF-ET.Methods: A retrospective and comparative study of 561 women accepted IVF/ICSI-ET treatment was carried out.A final diagnosis of intrauterine gestation was made by ultrasound on the 30th day after embryo transplanting in all the subjects,and of which,138 women got twin pregnancy without fetal reduction(group A),30 women got twin pregnancy with fetal reduction(group B),and 393 women got singleton pregnancy(group C).The abortion rate,premature birth rate,and natality of low birth weight among these groups were compared.Results: No significant differences were found in the abortion rate and premature rate between group A and group B.The abortion rate in the early phase of group A was not significantly higher than that in group C,except in the later phase.The premature rate and the natality of low birth weight in group A were significant higher than that in the group C,and the relative risk was 8.77 and 14.41 respectively.Conclusion: After IVF-ET,the risk of abortion and premature birth between twin pregnancy with and without fetal reduction has no significant difference,while the risks of abortion and premature birth of twin pregnancy were greatly higher than that of the singleton pregnancy respectively.Therefore,fetal reduction won't increase the abortion and premature birth risk,so it is feasible that women of twin pregnancy after IVF-ET receive fetal reduction.