Clinical observation of fosinopril used alone and combination with simvastatin in the treatment of patients with diabetic nephropathy

Objective To investigate the renal protective effects of fosinopril used alone and combination with simvastatin on patients with diabetic nephropathy.Methods Sixty patients with diabetic nephropating were randomly divided into two groups:30 patients in fosinopril group were treated with fosinopril 10 mg,po,qd; 30 patients in combination therapy group were treated with simvastation 20 mg,po,qd and fosinopril 10 mg,po,qd.The course of treatment was 24 weeks.The urinary albumin excretion rate (UAER),serum albumin(Alb),creatinine clearance(Ccr),serum creatinine(Scr),blood lipid and blood pressure were observed and recorded before and after the treatment.Results After the treatment,UAER,urine protein(UPT) decreased and the Alb increased in the two groups (P ＜ 0.01).But the UAER decreased in combination therapy group was better than that in fosinopril group group (P ＜ 0.01).Reduction of UPT and the Alb increased in combination therapy group were more than those in the fosinopril group (P ＜ 0.01).The Ccr and fasting blood glucose decreased in all groups,there was no significant difference between them (P ＞ 0.05).The blood lipid and pressure improved in two groups (P ＜ 0.01),especially in combination therapy group.Conclusions The combination treatment of simvastatin and fosinopril has synergestic effect on renal function protection in the treatment of diabetic nephropathy. Key words: Diabetic nephropathy ;  Fosinopril ;  Simvastatin ;