2010•Guoji mazuixue yu fusu zazhiRequires access
Neuroglobin——A new O_2-binding globin
Shouyuan Tian, Tie-hu Ye
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Abstract
In addition to the well known hemoglobin and myoglobin, neuroglobin is the third discovered oxygen-carrying globin, which is mainly expressed in brain. Because neuroglobin has a great affinity for oxygen, can reversibly bind oxygen and specifically supply oxygen to the brain, it plays an important part in uptake,transportation and utilization of oxygen in nerve tissues.The up-regulated expression of neuroglobin in human brain implies that neuroglobin plays an important role in protecting neurons from cerebral ischemia/hypoxia injury. It will provide new sights and approaches for the clinical study of ischemic/hypoxic injury of brain.
Key words:
Neuroglobin; Ischemia/Hypoxia; Brain; Neuroprotection