Roles and their mechanisms of neuroglobin in cerebral ischemia

Neuroglobin （Ngb） is an oxygen-carrying globin that specifically expresses in brain tissue. It is involved in energy metabolism, mitochondrial function, as well as cell survival and proliferation of signaling pathway regulation. Under physiological conditions, Ngb presents as a form of ferrous deoxy hexacoordination, which has stronger oxygen affinity. During ischemia and hypoxia, the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream, and plays a protective role for the damaged brain tissue. Key words: Nerve Tissue Proteins;  Globins;  Neuroglobin;  Brain Ischemia;  Signal Transduction; Neuroprotective Agents