Analysis of resistance of pseudomonas aeruginosa and its relationship with antimicrobial consumption from 2007 to 2012

Objective To study the trend of drug resistance of pseudomonas aeruginosa and its relationship with antimicrobial consumption,and provide a theoretical basis for rational use of antimicrobial drugs.Methods The annual consumption of antimicrobial drugs and trend of drug resistance of pseudomonas aeruginosa were analyzed from 2007 to 2012 retrospectively,and DDDs of antibiotics were calculated.The correlation between resistance of pseudomonas aeruginosa and DDDs of antibiotics was analyzed by Pearson correlation analysis.Results 3,745 strains of pseudomonas aeruginosa were mostly isolated from sputum specimens (79.1％),followed by secretion (13.7％).Strains were resistant to commonly used antimicrobial drugs in varying degrees from 2007 to 2012,and the majority of drug resistance rates declined since 2009.The resistance rates of piperacillin,aztreonam and tobramycin were higher,which fluctuated between 32.0％and 54.6％; the resistance rates of cefoperazone/sulbactam and amikacin were lower,which fluctuated between 13.4％ and 28.4％; strains showed a high resistance to carbapenems,which fluctuated between 15.3％ and 37.9％.DDDs of most antimicrobial drugs decreased in varying degrees since 2010.There were highly positive correlations between the resistance rates of pseudomonas aeruginosa and DDDs of ceftazidime and cefoperazone/sulbactam (r ＞ 0.800,P ＜ 0.05).Conclusions Pseudomonas aeruginosa was resistant to commonly used antibiotics in varying degrees,especially for carbapenems.Drug resistance of pseudomonas aeruginosa was associated with the consumption of antibiotics.Integrated management of antimicrobial application should be strengthened. Key words: Pseudomonas aeruginosa;  Antimicrobial;  DDDs;  Drug resistance