Surveillance of antimicrobial resistance to Pseudomonas aeruginosa in Anhui during 2008-2009

OBJECTIVE To investigate the trend of resistance to antimicrobial agents among clinical isolated Pseudomonas aeruginosa.METHODS Agar diffusion test was used to analyze the changes of antimicrobial susceptibility of P.aeruginosa from 30 hospitals in Anhui between 2008 and 2009.The resistance rate(R%),intermediate rate(I%) and susceptible rate(S%) of drugs were calculated according to the criteria in guidelines of CLSI(2009).The former two were then merged into one single group,and analyzed with SPSS 17.0 software.RESULTS With in the two years,a total of 121 strains and 198 strains of Pseudomonas aeruginosa were isolated separately in 2008 and 2009,while the detection rates were 13.4% and 16.0%.However,the statistics of multidrug resistant strains were 56(46.3%) and 49(24.8%) respectively;Amikacin,piperacillin-tazobactam,carbapenem antibiotic were the most active antimicrobial agents against P.aeruginosa.In comparison with 2008,the resistance rate of P.aeruginosa to cephalosporins,quinolones decreased in 2009.CONCLUSION Antimicrobial resistance of PAE is fairly serious;Rational use of antibiotics is an effective method of controlling the drug resistance.