The analysis of total body irradiation in the hematopoietic reconstitution and short-term side-effects of autologous stem cell transplantation

Objective To explore the influence of TBI in the conditioning regimen for autologous stem cell transplantation,as well as short-term side-effects.Methods To tally 103 patients were divided into TBI group and no TBI group with autologous stem cell transplantation during 1990-2012.The time required for hematopoietic reconstitution and the short-term side effects were analyzed.Results Between the two groups,the hematopoietic reconstitution time had no significant difference,but there was a high incidence of oral mucositis and gastrointestinal reaction in the TBI group (x2 =6.458,22.400,P ＜0.05),and the incidence of infection is not significant.Conclusions Given the preventive treatment,the TBI group has no more serious short-term side effects and better tolerance. Key words: Total body irradiation;  Autologous peripheral blood stem cell transplantation; Hematopoietic reconstitution;  Side-effects