Outcomes of preconditioning regimen with total body irradiation in treating T-cell lymphoma

Objective To investigate the clinical efficacy and safety of total body irradiation(TBI)-predominant preconditioning regimen in patients with T-cell lymphoma.Methods Data of 12 patients with T-cell lymphoma were retrospectively analyzed,who underwent TBI-predominant preconditioning regimen after autologous hematopoietic stem cell transplantation(AHSCT).The hematopoietic reconstitution,complications and survival were followed up.Results The hematopoietic reconstitution was successful.The time for ANC ≥0.5×109/L was 10-15 days and the time for platelet counts ≥20×109/L was 11-16 days after successful hematopoietic reconstitution.The patients were followed-up for 8-60 months with the recurrence rate of 25%(3/12),mortality rate of 16.7%(2/12),and 2-year disease-free survival rate of 75%(9/12).Conclusion The TBI-predominant preconditioning regimen is effective and safe in the treatment of T-cell lymphoma.