Clinical significance of prealbumin, enzymes, CRP detection in severe hand-foot-mouth disease children with myocardial injury

Objective To investigate the clinical significance of prealbumin (PA), enzymes, C-reactive protein (CRP) detection in severe hand-foot-mouth disease (HFMD) children with myocardial injury. Methods 183 children with HFMD were selected as the observation group, in which 54 children were severe, 129 cases were common.100 healthy children during the same period were selected as the control group.PA, α-acid dehydrogenase (α-HBDH), creatine kinase (CK), creatine kinase (CK-MB), CRP levels were detected in the serum of all subjects and compared. Results The serum level of PA in the observation group was (194.37±42.86)mg/L, which was significantly lower than (267.15±52.04)mg/L of the control group (t=5.942, P<0.05). The serum levels of α-HBDH, CK, CK-MB and CRP in the observation group were (261.58±61.40)U/L, (124.80±67.51)U/L, (38.79±16.26)U/L and (18.06±5.27)mg/L, which were significantly higher than those of the control group [(112.93±28.56)U/L, (103.94±60.86)U/L, (15.17±9.34)U/L and (4.82±0.95)mg/L, t=8.356, 5.087, 9.446 and 10.755, all P<0.05]. The serum PA level of the severe HFMD group was (144.92±40.36)mg/L, which was significantly lower than (230.89±46.27)mg/L of the ordinary HFMD group (t=7.035, P<0.05). The serum levels of α-HBDH, CK, CK-MB and CRP in the severe HFMD group were (301.58±71.40)U/L, (145.31±67.84)U/L, (43.66±18.95)U/L and (21.86±6.55)mg/L, which were significantly higher than those in the ordinary HFMD group [(162.93±28.56)U/L, (116.05±61.37)U/L, (24.75±12.04)U/L and (7.25±3.82)mg/L, t= 9.440, 6.204, 11.038 and 13.118, all P<0.05]. The serum PA level of the severe HFMD with myocardial injury group was (131.02±36.54)mg/L, which was significantly lower than (149.73±42.81)mg/L of the severe HFMD group (t=7.801, P<0.05). The serum levels of α-HBDH, CK, CK-MB and CRP in the severe HFMD with myocardial injury group were (327.84±74.95)U/L, (152.92±68.75)U/L, (45.17±20.68)U/L and (23.07±7.46)mg/L respectively, which were significantly higher than those in the severe HFMD group [(286.30±70.16)U/L, (134.80±66.31)U/L, (41.08±17.23)U/L and (20.95±6.20)mg/L, t=4.394, 5.938, 4.077 and 4.165, all P<0.05]. Conclusion Prealbumin, enzymes, CRP detection is favor of judgement the severity of HFMD children, and conducive to the early diagnosis of myocardial injury in children. Key words: Hand-foot-mouth disease; Myocardial injury; Prealbumin; Enzymes; C-Reactive protein