1999•实用儿科临床杂志Requires access

Correlation study on apoptosis of cerebral cortical cells and apoptosis of lymphocytes in neonatal pigs following perinatal asphyxia

余世禄, 王晓蕾, Taiping He, 刘晓平, LIU Kai, 唐方, 张俊梅

Abstract

目的探讨新生儿窒息时淋巴细胞调亡与脑细胞凋亡是否具相关性.以期寻求围生窒息时临床客观判定脑细胞凋亡的指标. 方法制作新生猪HIE模型,用琼脂电泳及流式细胞术对HIE新生猪及正常对照新生猪淋巴细胞及脑细胞凋亡进行定性、定量分析. 结果 HIE新生猪(n=15)淋巴细胞及脑细胞凋亡率均显著高于正常对照组(n=12).F=8.67 P《0.01,窒息新生猪淋巴细胞凋亡与脑细胞凋亡呈显著正相关,r=0.4007 P=0.038.结论体外淋巴细胞凋亡率可作为评估围生窒息新生儿活体内脑细肥凋亡状况的一项客观的临床指标.

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Key concepts: Apoptosis, Asphyxia, Perinatal asphyxia, Medicine, Cerebral cortex, Programmed cell death, Biology, Pathology