Incidence and risk factors of spontaneous bleeding in elderly patients with cerebral infarction treated by thrombolytic therapy

Objective To study the incidence and risk factors of spontaneous intracerebral hemorrhage in elderly patients with cerebral infarction treated by thrombolytic therapy. Methods A total of 146 patients with acute cerebral infarction treated by thrombolytic therapy in Xinxiang Central Hospital from September 2015 to January 2017 were divided into non bleeding group and hemorrhage group according to with spontaneous hemorrhage or not. Clinical indicators of the two groups were compared and analyzed single factor analysis, and the prognoses of the two groups were compared. Results According to Logistic by univariate analysis, with cerebral infarction converted into spontaneous bleeding as the dependent variable and the other factors as the independent variables, four risk factors were determined as risk factors: atrial fibrillation, history of cerebral white matter, anticoagulant therapy and large area of cerebral infarction. Markedly effective rate and total effective rate in the bleeding group (71.11%, 86.67%) were significantly higher than those in non bleeding group (37.35, 69.88%), the difference was statistically significant (P<0.05). Conclusions Atrial fibrillation, history of cerebral white matter, anticoagulation and large area of cerebral infarction are the risk factors of the conversion into spontaneous bleeding in elderly patients with cerebral infarction, which needs to be alerted. Key words: Non thrombolytic therapy; Cerebral infarction; Spontaneous hemorrhage; Risk factors