Expression of HIF-1α and PTEN in bnman multiple myeloma bone marrow

Objective To investigate HIF-1α and PTEN expression in multiple myeloma(MM).Methods The expression of HIF-1α and PTEN was studied in 28 cases of MM with immunohistochemistry.Results Over-expression of HIF-1α was frequently(20 of 28 cases,71.4%)detected in MM bone marrow.Expression of HIF-1α between MM and control group bone marrow has significant differences(P＜0.01).The positive expression rate of PTEN in MM bone marrow was 42.9%(12 0f 28 cases).Expression of PTEN between MM and control group bone marrow has significant difierences(P＜0.01).There was negative correlation between the expression of HIF-1α protein and the PTEN protein(P＜0.05,r=-0.542).Conclusion The absence or low expression of PTEN and the increased levels of HIF-1α may play a critical role in the formation.development and invasion of MM.HIF-1α and PTEN may be used to estimate the progress of MM. Key words: Multiple Myeloma; Hypoxia-inducible factor 1,alpha subunit; Phosphatase and tensin homology deleted on chromosome ten