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Advance of novel non-viral vector polyethylenimine in tumor gene delivery

姚元虎

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Abstract

基因治疗的关键之一是载体,聚乙烯亚胺(PEI)是重要的肿瘤基因治疗转导载体,在非病毒载体的研究中有重要的地位.聚乙烯亚胺有较强的结合DNA和黏附细胞的能力,具有较高的转导效率.尽管在体外聚乙烯亚胺转染真核细胞取得了很大的进步,但应用于体内基因转导仍然面临着如解剖大小的限制等一系列障碍。

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What this paper is about

基因治疗的关键之一是载体,聚乙烯亚胺(PEI)是重要的肿瘤基因治疗转导载体,在非病毒载体的研究中有重要的地位.聚乙烯亚胺有较强的结合DNA和黏附细胞的能力,具有较高的转导效率.尽管在体外聚乙烯亚胺转染真核细胞取得了很大的进步,但应用于体内基因转导仍然面临着如解剖大小的限制等一系列障碍。

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Available abstract

基因治疗的关键之一是载体,聚乙烯亚胺(PEI)是重要的肿瘤基因治疗转导载体,在非病毒载体的研究中有重要的地位.聚乙烯亚胺有较强的结合DNA和黏附细胞的能力,具有较高的转导效率.尽管在体外聚乙烯亚胺转染真核细胞取得了很大的进步,但应用于体内基因转导仍然面临着如解剖大小的限制等一系列障碍。

Key concepts: Polyethylenimine, Gene delivery, Viral vector, Vector (molecular biology), Genetic enhancement, Gene, Virology, Cancer research

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