2011•Journal of Biomedical EngineeringRequires access

Progress of Nanometer Vector Polyethylenimine Applied in Gene Therapy

Sun Yat-sen

Abstract

Polyethylenimine(PEI) is a kind of nanometer nonviral vector frequently applied in gene transfection.It is simple and easy to prepare and to modify and relatively safe compared to viral vectors.In recent years,PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain.This review reveales that the cytotoxicity and low transfection efficiency of PEI requires to be improved.However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.

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Key concepts: Polyethylenimine, Transfection, Genetic enhancement, Gene delivery, Viral vector, Vector (molecular biology), Nanotechnology, Adeno-associated virus