A single-center randomized controlled study of the effect of dyclonine hydrochloride mucilage on bubble removing in bowel preparation

Objective To evaluate the effect of two dosages of the dyclonine hydrochloride mucilage on removing bubbles in bowel preparation before colonoscopy. Methods Data of 774 patients who received colonoscopy from November 2015 to April 2016 in People′s Hospital of Xinjiang Uygur Autonomous Region were randomly divided into groups A, B and C. As the control group, group A only used four boxes of polyethylene glycol (PEG) for bowel preparation and drank 50 mL water after bowel preparation; group B was given 10 mL dyclonine hydrochloride mucilage with 50 mL water after four boxes of PEG for bowel preparation; group C was given 20 mL dyclonine hydrochloride mucilage with 50 mL water after four boxes of PEG. Intestinal cleanliness, intraluminal gas bubbles and satisfaction were graded by endoscopic physicians. Polyps of less than 5 mm were recorded and adverse reactions were observed. Results There were no significant differences in intestinal cleanliness among groups A, B and C (P>0.05). The intraluminal gas bubbles grading, physician satisfaction and detection rate of polyps of less than 5 mm of groups B and C were significantly better than those of group A(P<0.01), and group C was superior to group B in these variables(P<0.01). The proportion of level Ⅰ and Ⅱ in foam evaluation in group C was higher than that in group B(P<0.01). Conclusion Dyclonine hydrochloride mucilage can eliminate the bubbles inside the intestine, and the effect of 20 mL dyclonine hydrochloride mucilage for bowel preparation is superior to 10 mL. Key words: Colonoscopy; Dyclonine hydrochloride mucilage; Polyethylene glycol; Patient satisfaction