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Investigation of serum interleukin - 10 levels in neonatal hypoxic - ischemic encphalopathy and its clinical significance

Wang Cheng, 施长春, 倪宏, 水泉祥, 刘幸华, 汤小园, 黄艾美, 陈淑芳, 王爱珍

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Abstract

目的研究新生儿缺氧缺血性脑病(HIE)患儿血清白细胞介素10(IL-10)水平变化.方法采用ELISA法测定新生儿血清IL-10水平(HIE组20例和对照组20例标本均取自本院,分为HIE治疗前组、治疗后组和对照组).结果HIE治疗前组IL-10水平中位数为316pg/ml,明显高于对照组153pg/ml和治疗后组123.5pg/ml;对照组和治疗后组间差异无显著性.结论IL-10在新生儿HIE的发病机制中起重要作用.

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目的研究新生儿缺氧缺血性脑病(HIE)患儿血清白细胞介素10(IL-10)水平变化.方法采用ELISA法测定新生儿血清IL-10水平(HIE组20例和对照组20例标本均取自本院,分为HIE治疗前组、治疗后组和对照组).结果HIE治疗前组IL-10水平中位数为316pg/ml,明显高于对照组153pg/ml和治疗后组123.5pg/ml;对照组和治疗后组间差异无显著性.结论IL-10在新生儿HIE的发病机制中起重要作用.

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Available abstract

目的研究新生儿缺氧缺血性脑病(HIE)患儿血清白细胞介素10(IL-10)水平变化.方法采用ELISA法测定新生儿血清IL-10水平(HIE组20例和对照组20例标本均取自本院,分为HIE治疗前组、治疗后组和对照组).结果HIE治疗前组IL-10水平中位数为316pg/ml,明显高于对照组153pg/ml和治疗后组123.5pg/ml;对照组和治疗后组间差异无显著性.结论IL-10在新生儿HIE的发病机制中起重要作用.

Key concepts: Medicine, Clinical significance, Interleukin 1β, Interleukin, Internal medicine, Immunology, Cytokine

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