2003•Unpublished venueRequires access

Investigated of IL-2 and IL-6 on neonatal HIE,infection disease and premature infant

李杨方, 蔡芝兰, 潘晓洁, 倪林仙, 樊茂

Abstract

目的探讨新生儿缺氧缺血性脑病(HIE)、感染性疾病及早产儿血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)检测值的变化及临床意义,间接了解新生儿部分特异性及非特异性免疫功能.方法选择331例住院新生儿,分为HIE组、感染组、早产儿组,与30例健康新生儿对照,采用酶联免疫吸附法(ELISA)检测血清IL-2、IL-6的水平,进行对比分析.结果①患病新生儿IL-2明显低于正常新生儿,P＜0.01,有高度显著性差异,其中早产儿组最低仅为1.35 pg/ml;②感染组IL-6增高最为明显,与健康对照组相比,P＜0.01,有高度显著性差异,其中25例败血症患儿的IL-6均＞50 pg/ml.结论①新生儿感染性疾病、HIE及早产儿的免疫方面受到不同程度的损伤,介导特异性免疫的IL-2检测值低于健康新生儿;②本文首次报道早产儿IL-2检测值;③感染组介导天然免疫的IL-6高于健康新生儿,认为可作为早期诊断新生儿败血症的指标.

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Key concepts: Medicine, Disease, Premature newborn, Pediatrics, Internal medicine