2006•Unpublished venueRequires access
Evaluation of high-risk HPV testing in triage of patients with atypical squamous cells of undetermined significance
Jian-min Cen, De-ying Qian, Ding Wang, Re-hai Zeng, Aihua Lin, Yan-hong Shu, Dan-hua Hong
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Abstract
Objective
To evaluate high-risk HPV testing in triage of women with atypical squamous cells of undetermined significance(ASCUS).
Methods
High-risk HPV testing was performed reflexively on 654 liquid-based pap smears that had been interpreted as ASCUS. Final diagnosis was made by biopsy under the colposcopy.
Results
Of the 654 women with cytological ASCUS, 411(62. 8%)were positive by high-risk HPV testing. 58 cases were histologically confirmed as cervical intraepithelial neoplasia(CIN)(8. 9%,58/654). Of the 58 cases, 43(74. 1%)were diagnosed as CIN Ⅱ and CIN Ⅲ. By high-risk HPV testing, 80. 8% of CIN Ⅱ and 94. 1% of CIN Ⅲ were positive. The sensitivity to detect CIN was 88. 9% with HPV triage, and 65. 5% without HPV testing. The sensitivity to detect CIN Ⅱ and CIN Ⅱ I was 94. 1% by high-risk HPV testing and 65. 1% by colposcopic examination.
Conclusion
HPV DNA testing of high-risk types is a method of high sensitivity for identification of CIN Ⅱ and CIN Ⅲ in women with ASCUS. The application of HPV DNA testing will result in a reduction of colposcopy and biospy referrals.
Key words:
high-risk HPV test; atypical squamous cell of undetermined significance(ASCUS); cervical intraepithelial neoplasia(CIN); colposcopy; diagnosis