Effect of Bushen Tiaochong decoction combined with Guilu Bushen pills on symptom improvement and serum sex hormone levels in patients with perimenopausal dysfunctional uterine bleeding of kidney-yang deficiency type

Objective To investigate the effects of Bushen Tiaochong decoction combined with Guilu Bushen pills on symptom improvement and serum sex hormone levels in patients with perimenopausal dysfunctional uterine bleeding (PDUB) of kidney-yang deficiency type. Methods 86 patients with PDUB treated at our hospital from April 2016 to February, 2018 were selected, and were divided into a control group and an observation group using random number table method, with 43 cases for each group. The control group were treated with mifepristone; in addition, the observation group were treated with Bushen Tiaochong decoction and Guilu Bushen pills. The incidences of adverse reactions in the two groups were statistically analyzed; and the TCM symptom scores and serum sex hormone levels [progesterone (P), luteinizing hormone (LH), etc.], and changes in follicle stimulating hormone (FSH) and estrogen (E2) were compared with those of the patients with mild limbs, nocturia, frequent apathy, waist and knee acidity before and after the treatment. Results After the treatment, the scores of mental wilting, limbs without temperature, nocturia frequency, and waist and knee pain were (0.87±0.24), (0.76±0.21), (0.64±0.20), and (0.76±0.34) in the observation group, and were (1.85±0.52), (1.57±0.34), (1.08±0.37), and (1.06±0.43) in the control group. After the treatment, the levels of FSH, LH, P, and E2 were (4.79±1.54) IU/L, (4.24±1.26) IU/L, (6.38±1.35) nmol/L, and (171.06±14.66) pmol/L in the observation group, and were (7.26±1.72) IU/L, (6.61±1.46) IU/L, (9.82±1.87) nmol/L, and (268.25±18.46) pmol/L in the control group, with statistical differences (all P<0.05). The incidence of adverse reactions was 2.33% (1/43) in the observation group, and was 11.63% (5/43) in the control group, with a statistical difference (χ2=2.867, P=0.090). Conclusion Bushen Tiaochong decoction combined with Guilu Bushen pills in the treatment of kidney-yang deficiency type PDUB can significantly improve the patients’ symptoms and reduce serum sex hormone levels. Key words: Perimenopausal dysfunctional uterine bleeding; Bushen Tiaochong decoction; Guilu Bushen pills